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Publications


Knight AL, Yan X, Hamamichi S, Aijuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, Caldwell KA, Caldwell GA (2014) The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson's Models. Cell Metab . [ePub ahead of print]


Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S (2014) Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci USA . 111(11):4013-8


Bornhorst J, Chakraborty S, Meyer S, Lohren H, Große Brinkhaus S, Knight AL, Caldwell KA,Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M.(2014) The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.. Metallomics . 6(3):476-90


Thompson ML, Chen P, Borom AR, Roberts NB, Caldwell KA, Caldwell GA.(2014) TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.. Disease Models and Mechanisms. 7(2):233-43


Munoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Szewczyk NJ, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A.(2014) Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases. Antioxidants Redox Signaling. 20:217-35


Ray A, Martinez BA, Berkowitz LA, Caldwell GA, Caldwell KA.(2014) Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson’s model. Cell Death Disease. 5:e984


Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J.(2014) Potentiated HSP104 Variants ANtagonize Diverse Proteotoxic Misfolding Events. Cell . 156:170-182


Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet J-C, Buchwald SL, Lindquist S.(2013) Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates α-synuclein Toxicity in Neurons. Science . 342:979-83


Caldwell KA, Shu Y, Roberts NB, Caldwell GA, O'Donnell JM.(2013) Invertebrate Models of Dystonia. Curr Neuropharm. 11:16-29


Kautu BB, Carrasquilla A, Hicks ML, Caldwell KA, Caldwell GA.(2013) Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling. Neurosci Lett. 541:116-9


Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Lein C, Vila M, Bezard E.(2013) Lysosomal impairment in Parkinson's disease. Mov Disord. [ePub ahead of print]


Usenovic, M., Knight, A.L., Ray, A., Wong, V., Brown, K.R., Caldwell, G. A., Caldwell, K.A., Stagljar, I., and Krainc, D.(2012) Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. Human Molecular Genetics. 17:3785-3794


Dexter, P.M., Caldwell, K.A., and Caldwell, G.A. (2012) A Predictable Worm: Application of C. elegans to Mechanistic Investigation of Movement Disorders. Neurotherapeutics,  [ePub Apr 9] 393-404.

Harrington, A.J., Yacoubian, T.A., Sloan, S.R, Caldwell, K.A., and Caldwell, G.A. (2012) Functional analaysis of VPS41-mediated neuroprotection in C. elegans and mammalian models of Parkinson’s disease.  J. Neurosci.,   32:2142-2153.

Tardiff, D.F, Tucci, M.L. Caldwell, K.A., Caldwell, G.A., and Lindquist S. (2012) Different 8-hyroxyquinolines protect models of TDP-43, a-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.  J. Biol. Chem.  287:4107-2120.

Caldwell K.A. and Caldwell, G.A.  (2011).  Methodological strategies to evaluate functional effectors related to Parkinson’s disease through application of C. elegans models In Contemporary Animal Models of Movement Disorders: Methods and Protocols (Lane E. and Dunnett, S., eds.). Humana Press

Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, Dejager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S. Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast. Science. 2011 Oct 27. [Epub ahead of print]

Mazzulli, JR, Xu Y-H, Sun Y, Knight AL, McLean PJ, Caldwell GA, Grabowski GA, Krainc D  (2011).  Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.  Cell, 146:37-52.

Zheng M, Cierpicki T, Burdette AJ, Utepbergenov D, Janczyk PL, Derewenda U, Stukenberg PT, Caldwell KA, Derewenda ZS (2011).Structural Features and Chaperone Activity of the NudC Protein Family J Mol Biol. 409:722-741.

Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, Dawson, VL (2011) Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum. Mol. Genet., 20:3933-42.

Tucci, ML, Harrington, AJ, Caldwell, GA, Caldwell KA (2011) Modeling dopamine neuron degeneration in C. elegans.Methods in Molecular Biology., (Kawamata, H. and Manfredi, G.M., eds.) Humana Press.

Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, daHora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO (2011) TorsinA participates in endoplasmic reticulum-associated degradation (ERAD).  Nature Comm.

Harrington AJ, Knight AL, Caldwell GA, Caldwell KA (2011) C. elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson’s diseaseMethods, 53:220-225.

Caldwell GA, Caldwell KA (2010) Disinfecting dystonia? Drug discovery using worms identifies an antibiotic as a neuroprotective lead molecule for movement disorders.  Future Neurol. 5:473-476.

Tucci ML, Caldwell GA, Caldwell KA (2010) Cell culture to investigate neurotoxicity and neurodegeneration utilizing Caenorhabdidits elegans. In Cell Culture Techniques: Neuromethods.  Aschner M.

Chen P*, Burdette AJ*, Porter JC, Ricketts JC, Fox SA, Nery FC, Hewett JW, Breakefield XO, Caldwell KA, Caldwell GA (2010) The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Hum. Mol. Genet.  19:3502-3515.

Pivtoraiko VN, Harrington AJ, Mader BJ, Luker AM, Caldwell GA, Caldwell KA, Roth KA, Shacka JJ (2010) Low-dose bafilomycin attenuates neuronal cell death associated with autophagic-lysosome pathway dysfunction.  J. Neurochem. 114:1193-1204.

Cao S, Hewett JW, Yokoi F, Lu F, Buckley AC, Burdette AJ, Chen P, Nery FC, Li Y, Breakefield XO, Caldwell GA, Caldwell KA (2010) Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. Dis. Model. Mech. 3:386-396.

Burdette AJ, Churchill PF, Caldwell GA, Caldwell KA (2010) The early-onset torsion dystonia protein, torsinA, displays molecular chaperone activity in vitro. Cell Stress and Chaperones. 15:605-617.

Harrington AJ, Hamamichi S, Caldwell GA, Caldwell KA (2010) C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Dev. Dyn.  239:1282-1295.

Yacoubian TA, Sloan SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG (2010) Differential neuroprotective effects of 14-3-3 in models of Parkinson's disease. Cell Death Dis. 1:e2; doi:10.1038/cddis.2009.4

Su J, Auluck PK, Outerio TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet J-C, Lindquist S (2010) Compounds from an unbiased chemical screen reverse both ER-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.  Dis. Model. Mech. 37:330-338.

Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG (2010) VPS41, a protein involved in lysosomal trafficking,  is protective in mammalian cellular models of Parkinson's disease. Neurobiol. Dis. 37:330-338.

Locke CJ*, Kautu BB*, Berry KP, Lee SK, Caldwell KA, Caldwell GA (2009) Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in C. elegans GABAergic neurotransmission. Genetics. 183:1357-1372.

Caldwell KA, Tucci ML, Armagost J, Hodges TW, Chen J, Memon SB, Blalock JE, DeLeon SM, Findlay RF, Ruan Q, Webber PJ, Standaert DG, Olson JB, Caldwell GA (2009) Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.  PLoS ONE. 4:e7227.

Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S (2009) Rapid selection of cyclic peptide that reduce alpha-synuclein toxicity in yeast and animal models.  Nature Chemical Biology. 5:655-663.

Locke CJ, Caldwell KA, Caldwell GA (2009) The nematode, C. elegans, as an emerging model of seizures and epilepsy.  In Animal Models of Epilepsy: Methods and Innovations.  Neuromethods.  Baraban SC (ed.) Humana Press, Totowa, NJ. 40:1-25. 

Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet J-C, Lindquist S (2009) a-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nature Genetics. 41:308-315.

Faircloth LM, Churchill PF, Caldwell GA, Caldwell KA. (2009) The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro. Cell Stress and Chaperones. 14:95-103.

Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Wilson S, Yacoubian TA, Xie Z-L, Speake LD, Parks R, Crabtree D, Crimmins S, Uchiyama Y, Zhou Y, Peng L, Lu Y, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J (2008) A neuroprotective role of lysosomal enzyme cathepsin D against alpha-synuclein pathogenesis. Mol. Brain 1:17

Caldwell GA, Caldwell KA. (2008) Traversing a wormhole to combat Parkinson's disease. Disease Models Mech. 1:32-36

Berkowitz LA, Hamamichi S, Knight AL, Harrington AJ, Caldwell GA, Caldwell KA (2008) Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes. J Vis Exp. Jul 18;(17). pii: 835. doi: 10.3791/835

Berkowitz LA, Knight AL, Caldwell GA, Caldwell KA (2008) Generation of stable transgenic C. elegans using microinjection. J Vis Exp. Aug 15;(18). pii: 833. doi: 10.3791/833

Locke C, Berry K, Kautu B, Lee K, Caldwell K, Caldwell G (2008) Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants. J Vis Exp. Aug 15;(18). pii: 837. doi: 10.3791/837

Locke CJ, Fox SA, Caldwell GA, Caldwell KA. (2008) Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. Neurosci Lett. 439:129-33

Jinnah HA, Richter A, Mink JW, Caldwell GA, Caldwell KA, Gonzalez-Alegre, P, Cookson MR, Breakefield XO, DeLong MR, Hess EJ.  (2008) Animal Models for Drug Discovery in Dystonia. In Expert Opinion in Drug Discovery 3:83-97.

Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA. (2008) Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc Natl Acad Sci USA 105:728-33

Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. (2008) The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci USA 105:145-50

Howard RA, Sharma P, Hajjar C, Caldwell KA, Caldwell GA, du Breuil R, Moore R, Boyd L (2007) Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. BMC Cell Biol  8:32

Locke CJ, Williams SN, Schwarz EM, Caldwell GA, Caldwell KA (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Research, 1120:23-34.

Caldwell GA, Williams SN, Caldwell KA (2006) Integrated Genomics: A Discovery-Based Laboratory Course. Chichester, England (John Wiley & Sons publishers). Textbook.

Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Kolodner RD, Marsischky G, LaBaer J, Rochet J-C, Bonini NM, Lindquist S (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 Rescues Neuron Loss in Parkinson's Models. Science 313:324-328

Dickey CA, Yue M, Lin W-L, Dickson DW, Dunmore JH, Wing C, Lee CZ, West G, Cao S, Clark AMK, Caldwell KA, Caldwell GA, Eckman C, Patterson C, Hutton M, Petrucelli L (2006) Deletion of the ubiquitin ligase, CHIP, leads to accumulation, but not aggregation, of both endogenous phospho- and caspase-3 cleaved tau species. J. Neurosci. 26:6985-6996

Cao S, Gelwix CC, Caldwell KA, Caldwell GA (2005) Torsin-mediated protection from Cellular Stress in the Dopaminergic Neurons of Caenhorhabditis elegans.  J. Neurosci. 25:3801-3812

Locke CJ, Caldwell KA, Caldwell GA (2005) CarpeDB: A comprehensive database on the genetics of epilepsy. Nucleic Acids Res. 33:D5-24

Caldwell GA, Cao S, Izevbaye I, Caldwell KA (2005) Use of C. elegans to Model Human Movement Disorders. In Animal Models of Movement Disorders (LeDoux, M., ed.) Elsevier, New York, pp. 111-126

Caldwell GA, Cao S, Gelwix CC, Sexton EG, Caldwell KA (2004) An Animal Model to Discern Torsin Function: Suppression of Protein Aggregation in C. elegans. Adv. Neurol. 94:79-85

Zhang S, Keller CA, Yao CA, Caldwell GA, Chalfie M (2004) MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain. Curr. Biol. 14:1888-1896

Williams SN, Locke CJ, Braden AL, Caldwell KA, Caldwell GA (2004) Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in C. elegans. Hum. Mol. Genet., 13:2043-2059

Swatloski RP, Rogers RD, Holbrey JD, Turner MB, Memon SB, Caldwell GA, Caldwell KA (2004) Using Caenorhabditis elegans to Probe Toxicity of 1-alkyl-3-methylimidazolium Chloride Based Ionic Liquids. Chem. Comm. 6:689-690

Aumais JP, Williams, SN, Luo W, Nishino M, Caldwell, KA, Caldwell, GA, Lin S-H, Yu-Lee, L (2003) A Role for NudC, a Dynein-Associated Nuclear Movement Protein, in Mitosis and Cytokinesis. J. Cell Sci. 116:1991-2003

Caldwell GA, Cao S, Sexton EG, Gelwix CC, Bevel JP,Caldwell KA (2003) Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins. Hum. Mol. Genet. 12(3):307-319. Cover story

Caldwell GA (2003) As the Worm Turns: Discovering a Life of Discovery. The Washington & Lee Journal of Science 4:41-44

Dawe AL, Caldwell KA, Harris PM, Morris NR, Caldwell GA (2001) Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dev. Genes Evol. 211:434-441.